Somatostatin receptor scintigraphy screening in advanced hepatocarcinoma: A multi-center French study.
Identifieur interne : 000862 ( France/Analysis ); précédent : 000861; suivant : 000863Somatostatin receptor scintigraphy screening in advanced hepatocarcinoma: A multi-center French study.
Auteurs : Eric Nguyen-Khac [France] ; Isabelle Ollivier [France] ; Thomas Aparicio [France] ; Véronique Moullart [France] ; Alexis Hugentobler [France] ; Rachida Lebtahi [France] ; Céline Lobry [France] ; Christiane Susini [France] ; Christian Duhamel [France] ; Séverine Hommel [France] ; Jean François Cadranel [France] ; Jean-Paul Joly [France] ; Jean Claude Barbare [France] ; Blaise Tramier [France] ; Jean Louis Dupas [France]Source :
- Cancer Biology and Therapy [ 1538-4047 ] ; 2009-11.
Abstract
BACKGROUND: Somatostatin receptor scintigraphy (SRS) has been reported for receptor (SSTR) screening in advanced hepatocarcinoma (aHC) prior to somatostatin analogue treatment. AIMS: To evaluate SSTR screening with SRS in aHC patients. RESULTS: Seventy aHC patients (63 men) aged 65 +/- 11 y were included, with alcohol, viral or other causes cirrhosis in 35 (50%), 23 (33%), 12 (17%) cases respectively. CLIP score was 2.7 +/- 1.7, with more than three nodules in 37 (53%) cases. Largest nodule measured 7.6 +/- 4.5 cm. Median alpha-fetoprotein was 574 UI/mL. SRS was positive in 25/70 (35.7%) livers and 7/17 (41.2%) metastatic sites. Positive SRS patients differed from others for tumor size (9.2 +/- 4 vs. 6.7 +/- 4.6 cm, p = 0.03), prothrombin time (PT) (75.2 +/- 15.2 vs. 61.9 +/- 19%, p = 0.005), albumin (34.1 +/- 5.9 vs. 30.5 +/- 7.2 g/L, p = 0.04) and Child-Pugh (6.7 +/- 1.8 vs. 7.7 +/- 2.3, p = 0.04). After multivariate analysis, only PT was associated with positive SRS (p = 0.028). Immunohistochemistry was positive for SSTR2s in 6/7 tumors (SRS uptake in 5/6 cases). METHODS: SRS was performed prior treatment, with images at 4, 24 and 48 h. For seven tumors, SSTR2 subtype was detected immunohistochemically. CONCLUSIONS: In advanced hepatocarcinoma, we report SRS uptake in 35.7% of livers and 41.2% of metastatic sites. SRS value in screening patients for somatostatin analogue treatment remains to be assessed.
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Hal:inserm-00419507Le document en format XML
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01</addrLine><country key="FR"></country></address></desc><listRelation><relation active="#struct-300535" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-300535" type="direct"><org type="institution" xml:id="struct-300535" status="VALID"><orgName>CHU AMIENS</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Susini, Christiane" sort="Susini, Christiane" uniqKey="Susini C" first="Christiane" last="Susini">Christiane Susini</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-2893" status="OLD"><orgName>Biologie et Pathologie Digestive</orgName><desc><address><addrLine>Hopital de Rangueil 31432 TOULOUSE CEDEX 4</addrLine><country key="FR"></country></address><ref type="url">http://www-toulouse.inserm.fr/u531.asp</ref></desc><listRelation><relation active="#struct-217752" type="direct"></relation><relation active="#struct-300625" type="direct"></relation><relation name="U531" active="#struct-303623" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-217752" type="direct"><org type="institution" xml:id="struct-217752" status="VALID"> <orgName>Université Paul Sabatier - Toulouse 3</orgName> <orgName type="acronym">UPS</orgName> <desc> <address> <addrLine>118 route de Narbonne - 31062 Toulouse</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-tlse3.fr/</ref> </desc></org></tutelle><tutelle active="#struct-300625" type="direct"><org type="institution" xml:id="struct-300625" status="VALID"><orgName>IFR31</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle><tutelle name="U531" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Duhamel, Christian" sort="Duhamel, Christian" uniqKey="Duhamel C" first="Christian" last="Duhamel">Christian Duhamel</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-101674" status="INCOMING"><orgName>Service d'Hépato-Gastroentérologie</orgName><desc><address><addrLine>BP 24, Le Havre, F-76083 cedex</addrLine><country key="FR"></country></address></desc><listRelation><relation active="#struct-324517" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-324517" type="direct"><org type="institution" xml:id="struct-324517" status="INCOMING"><orgName>Groupe Hospitalier Le Havre</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Hommel, Severine" sort="Hommel, Severine" uniqKey="Hommel S" first="Séverine" last="Hommel">Séverine Hommel</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-95536" status="VALID"><orgName>Service d'Hépato-Gastroentérologie</orgName><desc><address><country key="FR"></country></address></desc><listRelation><relation active="#struct-300106" type="direct"></relation><relation active="#struct-300147" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-300106" type="direct"><org type="institution" xml:id="struct-300106" status="VALID"><orgName>Hôpital Charles Nicolle</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle><tutelle active="#struct-300147" type="direct"><org type="institution" xml:id="struct-300147" status="VALID"><orgName>CHU Rouen</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Cadranel, Jean Francois" sort="Cadranel, Jean Francois" uniqKey="Cadranel J" first="Jean François" last="Cadranel">Jean François Cadranel</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-101676" status="INCOMING"><orgName>Service d'Hépato-Gastroentérologie</orgName><desc><address><addrLine>boulevard Laennec, Creil F-60100</addrLine><country key="FR"></country></address></desc><listRelation><relation active="#struct-324518" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-324518" type="direct"><org type="institution" xml:id="struct-324518" status="INCOMING"><orgName>CH Laennec de Creil</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Joly, Jean Paul" sort="Joly, Jean Paul" uniqKey="Joly J" first="Jean-Paul" last="Joly">Jean-Paul Joly</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-101666" status="INCOMING"><orgName>Service d'Hépato-Gastroentérologie</orgName><desc><address><addrLine>place Victor Pauchet, Amiens, F-80054 cedex 01</addrLine><country key="FR"></country></address></desc><listRelation><relation active="#struct-300535" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-300535" type="direct"><org type="institution" xml:id="struct-300535" status="VALID"><orgName>CHU AMIENS</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Barbare, Jean Claude" sort="Barbare, Jean Claude" uniqKey="Barbare J" first="Jean Claude" last="Barbare">Jean Claude Barbare</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-101678" status="INCOMING"><orgName>Service d'Hépato-Gastroentérologie CH Compiègne</orgName><desc><address><addrLine>8 avenue Henri Adnot, Compiègne F-60200</addrLine><country key="FR"></country></address></desc><listRelation><relation active="#struct-324512" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-324512" type="direct"><org type="institution" xml:id="struct-324512" status="INCOMING"><orgName>CH COMPIEGNE</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Tramier, Blaise" sort="Tramier, Blaise" uniqKey="Tramier B" first="Blaise" last="Tramier">Blaise Tramier</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-101679" status="INCOMING"><orgName>Service de Biostatistiques</orgName><desc><address><addrLine>place Victor Pauchet, Amiens, F-80054 cedex 01</addrLine><country key="FR"></country></address></desc><listRelation><relation active="#struct-300535" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-300535" type="direct"><org type="institution" xml:id="struct-300535" status="VALID"><orgName>CHU AMIENS</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Dupas, Jean Louis" sort="Dupas, Jean Louis" uniqKey="Dupas J" first="Jean Louis" last="Dupas">Jean Louis Dupas</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-101666" status="INCOMING"><orgName>Service d'Hépato-Gastroentérologie</orgName><desc><address><addrLine>place Victor Pauchet, Amiens, F-80054 cedex 01</addrLine><country key="FR"></country></address></desc><listRelation><relation active="#struct-300535" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-300535" type="direct"><org type="institution" xml:id="struct-300535" status="VALID"><orgName>CHU AMIENS</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author></analytic><series><title level="j">Cancer Biology and Therapy</title><idno type="ISSN">1538-4047</idno><imprint><date type="datePub">2009-11</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">BACKGROUND: Somatostatin receptor scintigraphy (SRS) has been reported for receptor (SSTR) screening in advanced hepatocarcinoma (aHC) prior to somatostatin analogue treatment. AIMS: To evaluate SSTR screening with SRS in aHC patients. RESULTS: Seventy aHC patients (63 men) aged 65 +/- 11 y were included, with alcohol, viral or other causes cirrhosis in 35 (50%), 23 (33%), 12 (17%) cases respectively. CLIP score was 2.7 +/- 1.7, with more than three nodules in 37 (53%) cases. Largest nodule measured 7.6 +/- 4.5 cm. Median alpha-fetoprotein was 574 UI/mL. SRS was positive in 25/70 (35.7%) livers and 7/17 (41.2%) metastatic sites. Positive SRS patients differed from others for tumor size (9.2 +/- 4 vs. 6.7 +/- 4.6 cm, p = 0.03), prothrombin time (PT) (75.2 +/- 15.2 vs. 61.9 +/- 19%, p = 0.005), albumin (34.1 +/- 5.9 vs. 30.5 +/- 7.2 g/L, p = 0.04) and Child-Pugh (6.7 +/- 1.8 vs. 7.7 +/- 2.3, p = 0.04). After multivariate analysis, only PT was associated with positive SRS (p = 0.028). Immunohistochemistry was positive for SSTR2s in 6/7 tumors (SRS uptake in 5/6 cases). METHODS: SRS was performed prior treatment, with images at 4, 24 and 48 h. For seven tumors, SSTR2 subtype was detected immunohistochemically. CONCLUSIONS: In advanced hepatocarcinoma, we report SRS uptake in 35.7% of livers and 41.2% of metastatic sites. SRS value in screening patients for somatostatin analogue treatment remains to be assessed.</div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><country name="France"><noRegion><name sortKey="Nguyen Khac, Eric" sort="Nguyen Khac, Eric" uniqKey="Nguyen Khac E" first="Eric" last="Nguyen-Khac">Eric Nguyen-Khac</name></noRegion><name sortKey="Aparicio, Thomas" sort="Aparicio, Thomas" uniqKey="Aparicio T" first="Thomas" last="Aparicio">Thomas Aparicio</name><name sortKey="Barbare, Jean Claude" sort="Barbare, Jean Claude" uniqKey="Barbare J" first="Jean Claude" last="Barbare">Jean Claude Barbare</name><name sortKey="Cadranel, Jean Francois" sort="Cadranel, Jean Francois" uniqKey="Cadranel J" first="Jean François" last="Cadranel">Jean François Cadranel</name><name sortKey="Duhamel, Christian" sort="Duhamel, Christian" uniqKey="Duhamel C" first="Christian" last="Duhamel">Christian Duhamel</name><name sortKey="Dupas, Jean Louis" sort="Dupas, Jean Louis" uniqKey="Dupas J" first="Jean Louis" last="Dupas">Jean Louis Dupas</name><name sortKey="Hommel, Severine" sort="Hommel, Severine" uniqKey="Hommel S" first="Séverine" last="Hommel">Séverine Hommel</name><name sortKey="Hugentobler, Alexis" sort="Hugentobler, Alexis" uniqKey="Hugentobler A" first="Alexis" last="Hugentobler">Alexis Hugentobler</name><name sortKey="Joly, Jean Paul" sort="Joly, Jean Paul" uniqKey="Joly J" first="Jean-Paul" last="Joly">Jean-Paul Joly</name><name sortKey="Lebtahi, Rachida" sort="Lebtahi, Rachida" uniqKey="Lebtahi R" first="Rachida" last="Lebtahi">Rachida Lebtahi</name><name sortKey="Lobry, Celine" sort="Lobry, Celine" uniqKey="Lobry C" first="Céline" last="Lobry">Céline Lobry</name><name sortKey="Moullart, Veronique" sort="Moullart, Veronique" uniqKey="Moullart V" first="Véronique" last="Moullart">Véronique Moullart</name><name sortKey="Ollivier, Isabelle" sort="Ollivier, Isabelle" uniqKey="Ollivier I" first="Isabelle" last="Ollivier">Isabelle Ollivier</name><name sortKey="Susini, Christiane" sort="Susini, Christiane" uniqKey="Susini C" first="Christiane" last="Susini">Christiane Susini</name><name sortKey="Tramier, Blaise" sort="Tramier, Blaise" uniqKey="Tramier B" first="Blaise" last="Tramier">Blaise Tramier</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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